Site-Specific Induction of Metallothionein in N-Nitrosodimethylamine-Treated Rat Liver.
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چکیده
منابع مشابه
Induction and Synthesis of Metallothionein in Isolated Perfused Rat Liver*
The induction and synthesis of metallothionein was studied in the isolated perfused rat liver, using Cd(I1) as the inducing metal. Perfusing the liver with 25 to 100 pg of Cd(I1) for 180 min revealed that the amount of Cd(I1) in metallothionein increased with the dosage of Cd(II), saturation being achieved at 75 pg. Zn(I1) in metallothionein decreased to about 60% of the level found in control ...
متن کاملInduction and synthesis of metallothionein in isolated perfused rat liver.
The induction and synthesis of metallothionein was studied in the isolated perfused rat liver, using Cd(I1) as the inducing metal. Perfusing the liver with 25 to 100 pg of Cd(I1) for 180 min revealed that the amount of Cd(I1) in metallothionein increased with the dosage of Cd(II), saturation being achieved at 75 pg. Zn(I1) in metallothionein decreased to about 60% of the level found in control ...
متن کاملMetabolic denitrosation of N-nitrosodimethylamine in vivo in the rat.
Enzymatic denitrosation is a potentially inactivating metabolic route that has been shown to convert carcinogenic N-nitrosodimethylamine (NDMA) to methylamine (MA) in vitro. To investigate its quantitative course in vivo, groups of 8-week-old male Fischer rats have been given small (8-15 mumol/kg) p.o. or i.v. bolus doses of 14C-labeled NDMA and the subsequent formation of radioactive MA has be...
متن کاملRegulation of A^-Nitrosodimethylamine Demethylase in Rat Liver and Kidney1
In previous work, the low k„, form of /V-nitrosodimethylamine (NDMA) demethylase has been demonstrated to be due to a specific form of cytochrome P-450 (designated as P-450ac) and to be the enzyme required for the metabolic activation of NDMA. The present work deals with the regulation of P-450ac in rat liver during development as well as the mechanism of induction of P-450ac in rat liver and...
متن کاملInduction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization.
The N-nitrosodimethylamine demethylase (P450I-IE1) is induced severalfold in liver by giving rats ethanol, acetone, pyrazole, and other related small molecular weight compounds. This induction is not the result of an increase in IIE1 mRNA, but could be due to either an increase in translation rate or a decrease in protein degradation. To determine the mechanism of induction, we measured IIE1 sy...
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ژورنال
عنوان ژورنال: Journal of Health Science
سال: 2003
ISSN: 1344-9702,1347-5207
DOI: 10.1248/jhs.49.160